Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 19/20 | 0.62 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.45 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.43 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868766 | 0.92 | EIF2AK3 (0.74) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868270 | 0.85 | EIF2AK3 (0.76) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868471 | 0.84 | EIF2AK3 (0.80) | EIF2AK3EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868231 | 0.82 | EIF2AK3 (0.76) | EIF2AK3EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868648 | 0.81 | EIF2AK3 (0.69) | EIF2AK3EIF2AK2 | |
| SCHEMBL868848 | 0.80 | EIF2AK3 (0.72) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL2374504 | 0.78 | EIF2AK3 (0.67) | EIF2AK3EIF2AK2EIF2AK1RIPK1 | |
| SCHEMBL868634 | 0.77 | EIF2AK3 (1.00) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL27975781 | 0.77 | EIF2AK3 (0.64) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 | |
| SCHEMBL868763 | 0.76 | EIF2AK3 (0.76) | EIF2AK3EIF2AK2EIF2AK1RIPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |