Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 10/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29904835 | 0.87 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL14759956 | 0.87 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL14769541 | 0.85 | AHR (0.35) | KDM4ESMN1; SMN2KMT2AGAAMEN1 | |
| SCHEMBL14816677 | 0.84 | KDM4E (0.47) | KDM4ENQO2ABL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16476633 | 0.84 | KDM4E (0.33) | KDM4ESMN1; SMN2ALDH1A1MAPTMAPK1 | |
| SCHEMBL16476635 | 0.80 | KDM4E (0.43) | KDM4ENQO2ABL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31347233 | 0.77 | KDM4E (0.46) | KDM4ENQO2ABL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL26104506 | 0.77 | KDM4E (0.46) | KDM4ENQO2ABL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25211367 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1MAPK1GAATSHR | |
| SCHEMBL30989273 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1MAPK1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846712-B2 | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors | SANOFI (FR) | 2014-09-30 | — | — | US | disclosed |
| EP-2567959-B1 | 6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2014-04-16 | — | — | EP | disclosed |
| US-20130065894-A1 | 6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI (FR) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065894-A1 | 6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | MAP3K1, MAP4K2, MAP3K6 | KDM4E 1053/4885NQO2 673/4885ABL1 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.