Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CFB | P00751 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16343134 | 1.00 | DRD2 (0.45) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL16343236 | 1.00 | DRD2 (0.45) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL16343091 | 0.90 | DRD2 (0.54) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL14838834 | 0.88 | GBA1 (0.44) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL16343084 | 0.88 | CRHBP (0.42) | DRD2DRD3DRD4HRH3MAPT | |
| SCHEMBL16342872 | 0.88 | DRD2 (0.45) | DRD2DRD3DRD4HRH3HCRTR1 | |
| SCHEMBL16343527 | 0.88 | DRD2 (0.45) | DRD2DRD3DRD4HRH3HCRTR1 | |
| SCHEMBL16343162 | 0.88 | DRD2 (0.45) | DRD2DRD3DRD4HRH3OPRM1 | |
| SCHEMBL16343041 | 0.88 | DRD2 (0.45) | DRD2DRD3DRD4HRH3HCRTR1 | |
| SCHEMBL16343030 | 0.87 | HCRTR1 (0.52) | DRD2DRD3DRD4MAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | claimed |
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | disclosed |
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | disclosed |
| US-9527850-B2 | Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist | MERCK PATENT GMBH (DE) | 2016-12-27 | — | — | US | disclosed |
| EP-2844648-B1 | BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST | MERCK PATENT GMBH (DE) | 2016-11-09 | — | — | EP | disclosed |
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011557-A1 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist | LPAR1, LPAR2, LPAR5 | DRD2 2149/4885DRD3 3500/4885DRD4 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.