Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15135705 | 0.85 | LMNA (0.42) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL16344790 | 0.85 | MAPT (0.50) | MAPTALDH1A1MAPK1HPGDSMN1; SMN2 | |
| SCHEMBL15135706 | 0.85 | LMNA (0.42) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL15135764 | 0.82 | PRMT1 (0.51) | MAPTLMNA | |
| SCHEMBL15143867 | 0.80 | ALDH1A1 (0.40) | MAPTALDH1A1LMNAADORA2AMEN1 | |
| SCHEMBL15156343 | 0.79 | LMNA (0.43) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL15156341 | 0.79 | LMNA (0.43) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL15136115 | 0.79 | LMNA (0.44) | MAPTALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL15156135 | 0.78 | EGFR (0.40) | MAPTALDH1A1LMNA | |
| SCHEMBL15156138 | 0.78 | EGFR (0.40) | MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144451-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS LLC | 2019-05-16 | — | — | US | disclosed |
| US-20180037583-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS LLC (US) | 2018-02-08 | — | — | US | disclosed |
| US-20180037583-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS LLC (US) | 2018-02-08 | — | — | US | disclosed |
| US-9637487-B2 | Purinone compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-05-02 | — | — | US | disclosed |
| US-9637487-B2 | Purinone compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160168149-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS LLC | 2016-06-16 | — | — | US | disclosed |
| US-20160168149-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS LLC | 2016-06-16 | — | — | US | disclosed |
| EP-3016953-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | Pharmacyclics, LLC (US) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015002894-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2015-01-08 | — | — | WO | disclosed |
| WO-2015002894-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037583-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | BTK, LCK, BCL9 | MAPT 4542/4885ALDH1A1 3729/4885MAPK1 868/4885 |
| US-20190144451-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | BTK, LCK, BCL9 | MAPT 4542/4885ALDH1A1 3729/4885MAPK1 868/4885 |
| US-20160168149-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | BTK, LCK, BCL9 | MAPT 4542/4885ALDH1A1 3729/4885MAPK1 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.