Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | LDHB | P07195 | 1/20 | 0.54 |
| ▸ | NADK | O95544 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.49 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.49 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL15279 | 0.90 | ADH1A (0.75) | ADH1ALMNAPMP22TP53TSHR | |
| Adenine SCHEMBL23041044 | 0.89 | ADH1A (0.74) | ADH1ALMNAPMP22TP53TSHR | |
| Adenine SCHEMBL851383 | 0.89 | ADH1A (0.74) | ADH1ALMNAPMP22TP53TSHR | |
| Niacinamide SCHEMBL14861027 | 0.84 | ADH1A (0.84) | ADH1ALMNAPMP22TP53TSHR | |
| SCHEMBL8505460 | 0.84 | ADH1A (0.81) | ADH1ALMNAPMP22TP53TSHR | |
| SCHEMBL755569 | 0.83 | ADH1A (0.98) | ADH1ALMNAPMP22TP53TSHR | |
| Adenine SCHEMBL30498936 | 0.83 | ADH1A (0.73) | ADH1ALMNAPMP22TP53TSHR | |
| SCHEMBL4595394 | 0.83 | ADH1A (0.81) | ADH1ALMNAPMP22TP53TSHR | |
| SCHEMBL1276381 | 0.82 | ADH1A (1.00) | ADH1ALMNAPMP22TP53TSHR | |
| SCHEMBL20202727 | 0.82 | ADH1A (1.00) | ADH1ALMNAPMP22TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608682-A1 | A FOOD PRODUCT COMPRISING A LOW TEMPERATURE RICE PROTEIN CONCENTRATE | Danisco US Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-20130142903-A1 | FOOD PRODUCT COMPRISING A LOW TEMPERATURE RICE PROTEIN CONCENTRATE | DANISCO US INC (US) | 2013-06-06 | — | — | US | disclosed |
| WO-2012027226-A1 | A FOOD PRODUCT COMPRISING A LOW TEMPERATURE RICE PROTEIN CONCENTRATE | DANISCO US INC. (US) | 2012-03-01 | — | — | WO | disclosed |