Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218427 | 0.86 | ALDH1A1 (0.45) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16345750 | 0.81 | F2RL3 (0.45) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL28730184 | 0.79 | F2RL3 (0.44) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3705592 | 0.79 | IDO1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL20562110 | 0.79 | KDM4E (0.44) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL18325768 | 0.78 | SLC22A12 (0.48) | F2RL3ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7427465 | 0.78 | F2RL3 (0.43) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7428362 | 0.77 | ERN1 (0.44) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6604398 | 0.77 | F2RL3 (0.43) | F2RL3ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL2173838 | 0.77 | PDE4B (0.50) | F2RL3ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016946-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics, Inc. (US) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015003166-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2015-01-08 | — | — | WO | disclosed |