Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16346414 | 0.85 | MAPK1 (0.47) | MAPK1PDE7APGRNPC1RAB9A | |
| SCHEMBL16116776 | 0.85 | CYP1A2 (0.51) | MAPK1PDE7APGRNPC1RAB9A | |
| SCHEMBL19373335 | 0.83 | MAPK1 (0.52) | MAPK1PDE7APGRNPC1RAB9A | |
| SCHEMBL16345901 | 0.80 | PIK3CD (0.41) | PDE7A | |
| SCHEMBL16345830 | 0.79 | PIK3CD (0.37) | PDE7AALDH1A1LMNATP53POLB | |
| SCHEMBL28866367 | 0.76 | MAPK1 (0.55) | MAPK1PDE7APGRNPC1RAB9A | |
| SCHEMBL16346179 | 0.73 | NPC1 (0.67) | MAPK1PDE7ANPC1RAB9AALDH1A1 | |
| SCHEMBL30160665 | 0.71 | MAPK1 (0.53) | MAPK1PGRPIM1ALDH1A1KDM4E | |
| SCHEMBL28513461 | 0.71 | MAPK1 (0.53) | MAPK1PGRPIM1ALDH1A1KDM4E | |
| SCHEMBL16386794 | 0.71 | MAPK1 (0.49) | MAPK1PDE7APGRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016955-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015001491-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2015-01-08 | — | — | WO | disclosed |