Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | APOL1 | O14791 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252334 | 0.87 | TRPV1 (0.47) | — | |
| SCHEMBL16375412 | 0.86 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9AHPGDHDAC1 | |
| SCHEMBL18329186 | 0.85 | EPHX2 (0.40) | CTSLNPC1PKMRAB9AHDAC3 | |
| SCHEMBL16346744 | 0.85 | OGG1 (0.46) | CTSLALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL16346728 | 0.85 | POLB (0.47) | ALDH1A1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL16346499 | 0.85 | TRPV1 (0.38) | CTSLNPC1RAB9AEPHX2HTT | |
| SCHEMBL16376235 | 0.84 | POLB (0.53) | CTSLNPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL13525247 | 0.84 | ANO1 (0.36) | CTSLNPC1PKMRAB9AEPHX2 | |
| SCHEMBL16346463 | 0.82 | PLK1 (0.49) | ALDH1A1NPC1PKMRAB9AHPGD | |
| SCHEMBL16340916 | 0.82 | EPHX2 (0.50) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368868-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universite Zurich (CH) | 2016-12-22 | — | — | US | claimed |
| EP-3016514-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universität Zürich (CH) | 2016-05-11 | — | — | EP | claimed |
| WO-2015000929-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universität Zürich (CH) | 2015-01-08 | — | — | WO | claimed |
| US-20160368868-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universite Zurich (CH) | 2016-12-22 | — | — | US | disclosed |
| US-20160368868-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universite Zurich (CH) | 2016-12-22 | — | — | US | disclosed |
| US-20160368868-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universite Zurich (CH) | 2016-12-22 | — | — | US | disclosed |
| EP-3016514-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universität Zürich (CH) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015000929-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universität Zürich (CH) | 2015-01-08 | — | — | WO | disclosed |
| WO-2015000929-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | Universität Zürich (CH) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368868-A1 | N-(1-CYANO-2-HYDROXY-1-METHYL-ETHYL)-4-(TRIFLUOROMETHYLSULFANYL)BENZAMIDE DERIVATIVES FOR USE AS NEMATOCIDAL DRUGS | HRH4, HRH2, CNR1 | CTSL 893/4885APOL1 4388/4885ALDH1A1 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.