Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.48 |
| ▸ | CDK1 | P06493 | 6/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.48 |
| ▸ | CCND1 | P24385 | 6/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CCND2 | P30279 | 2/20 | 0.43 |
| ▸ | CCND3 | P30281 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632749 | 0.91 | JAK2 (0.50) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1633698 | 0.88 | CDK4 (0.48) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL13498321 | 0.86 | CDK2 (0.52) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1633275 | 0.86 | CDK4 (0.50) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1865423 | 0.85 | CDK4 (0.61) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1635198 | 0.83 | TBK1 (0.56) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1632409 | 0.81 | JUN (0.49) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1633593 | 0.79 | MAPK10 (0.46) | CDK4CDK1CCND1CCNE1CDK2 | |
| SCHEMBL1633297 | 0.78 | TBK1 (0.47) | CDK4CDK1CCNB1CCND1CCNE1 | |
| SCHEMBL1632752 | 0.78 | SYK (0.45) | CDK4CDK1CCNB1CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |