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Leucine

Leucine

SCHEMBL16348676

CC(C)C[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)OC(=O)CN.C[C@@H](OC(=O)[C@@H](N)CCCNC(=N)N)[C@H](N)C(=O)O

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 7/20 0.33
▸ NPY1R P25929 5/20 0.33
▸ NPY2R P49146 4/20 0.31
▸ NPY5R Q15761 4/20 0.31
▸ SLC7A5 Q01650 1/20 0.31
▸ FOLH1 Q04609 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valine SCHEMBL10883242 0.88 — —
Aspartic Acid SCHEMBL11135113 0.87 — —
SCHEMBL2125107 0.84 NPY4R (0.39) NPY4RNPY1RNPY2RNPY5RSLC7A5
SCHEMBL1964090 0.82 NPY4R (0.34) NPY4RNPY1RNPY2RNPY5R
Arginine SCHEMBL28705204 0.81 SLC7A5 (0.45) NPY4RNPY1RNPY2RNPY5RSLC7A5
SCHEMBL16876652 0.80 GSR (0.38) —
Arginine SCHEMBL904454 0.80 OTC (0.41) NPY4RNPY1RNPY2RNPY5R
SCHEMBL1965668 0.80 NPY4R (0.38) NPY4RNPY1RNPY2RNPY5R
Leucine SCHEMBL15323685 0.79 SLC7A5 (0.47) SLC7A5FOLH1
Arginine SCHEMBL9551434 0.79 GSR (0.37) NPY4RNPY1RNPY2RNPY5RSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8933193-B2 Lantibiotics and uses thereof REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2015-01-13 — — US disclosed
US-20110305763-A1 LANTIBIOTICS AND USES THEREOF REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2011-12-15 — — US disclosed