Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | FLT4 | P35916 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470454 | 0.91 | VCP (0.69) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL16349075 | 0.90 | VCP (0.53) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL5469457 | 0.90 | VCP (0.68) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL16349171 | 0.89 | ACVR1 (0.56) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL5472158 | 0.89 | VCP (0.67) | VCPIMPDH2KDRFLT1FLT4 | |
| SCHEMBL16348972 | 0.89 | VCP (0.51) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL16349128 | 0.88 | VCP (0.60) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL16349076 | 0.88 | VCP (0.50) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL16349121 | 0.88 | VCP (0.50) | VCPACVR1TGFBR1IMPDH2ACVRL1 | |
| SCHEMBL16348973 | 0.87 | VCP (0.59) | VCPACVR1TGFBR1IMPDH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189712-B2 | 1,3-Oxazole compounds for the treatment of cancer | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |