Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | FLT1 | P17948 | 7/20 | 0.58 |
| ▸ | FLT4 | P35916 | 7/20 | 0.58 |
| ▸ | VCP | P55072 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186215 | 0.87 | KDR (0.59) | KDRFLT1FLT4VCPJAK2 | |
| SCHEMBL5469332 | 0.86 | FLT1 (0.58) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL16349084 | 0.85 | VCP (0.62) | KDRFLT1FLT4VCPJAK2 | |
| SCHEMBL16349169 | 0.82 | VCP (0.62) | KDRFLT1FLT4VCPSIGMAR1 | |
| SCHEMBL27965095 | 0.77 | SIGMAR1 (0.71) | SIGMAR1JAK2SYK | |
| SCHEMBL11552590 | 0.76 | NOTUM (0.53) | SIGMAR1CCNCCDK8 | |
| Gw549390X SCHEMBL3295009 | 0.75 | KDR (1.00) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5465177 | 0.75 | VCP (0.66) | KDRFLT1FLT4VCPSIGMAR1 | |
| SCHEMBL5185601 | 0.74 | KDR (0.68) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5465342 | 0.74 | VCP (0.64) | KDRFLT1FLT4VCPSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189712-B2 | 1,3-Oxazole compounds for the treatment of cancer | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |