Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14609556 | 0.90 | CDYL (0.33) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14609555 | 0.88 | ALDH1A1 (0.34) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13234058 | 0.84 | ALDH1A1 (0.43) | MAPTLMNAKDM4EGLO1ALDH1A1 | |
| SCHEMBL4512676 | 0.84 | MAPT (0.41) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16315764 | 0.80 | POLB (0.46) | MAPTLMNAKDM4EGLO1ALDH1A1 | |
| SCHEMBL13233963 | 0.76 | HSPA9 (0.43) | MAPTLMNAGLO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12659870 | 0.76 | MAPT (0.46) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL12659939 | 0.74 | PPARG (0.48) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14609178 | 0.74 | CDYL (0.33) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13234018 | 0.74 | MAPT (0.42) | MAPTLMNAALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749994-B2 | Pentacyclic kinase inhibitors | GENENTECH, INC. (US) | 2010-07-06 | — | — | US | disclosed |