HSPA9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Sheta-2 (SCHEMBL13417328)	1.00	7/20
SCHEMBL13417330	0.81	7/20
SCHEMBL12496803	0.42	6/20
SCHEMBL12155549	0.47	5/20
SCHEMBL10882763	0.40	5/20
SCHEMBL6830091	0.67	4/20
SCHEMBL1396636	0.62	4/20
SCHEMBL7195612	0.49	4/20
SCHEMBL6295866	0.49	4/20
SCHEMBL7340428	0.47	4/20
SCHEMBL7340432	0.47	4/20
SCHEMBL3714772	0.46	4/20
SCHEMBL10698510	0.44	4/20
SCHEMBL4603531	0.43	4/20
SCHEMBL4092040	0.43	4/20
SCHEMBL6669541	0.42	4/20
SCHEMBL7379174	0.41	4/20
SCHEMBL2578045	0.41	4/20
Perchlorate (SCHEMBL7652081)	0.40	4/20
SCHEMBL397152	0.40	4/20

Clinical trials — most relevant to HSPA9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin	PHASE2/PHASE3	UNKNOWN
Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients	PHASE3	WITHDRAWN
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease	PHASE3	RECRUITING
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease	nan	COMPLETED
Local Heat-Stress as a Mechanism of Hearing Preservation	nan	WITHDRAWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Oral Glutamine in Cardiopulmonary Bypass	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis	nan	NOT_YET_RECRUITING
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC	nan	COMPLETED
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a HSPA9 binder may also engage these)

Protein	Name	Similarity
P38647	—	1.000	P38647 →
O35501	—	1.000	O35501 →
Q5R511	—	1.000	Q5R511 →
P48721	—	1.000	P48721 →
Q3ZCH0	—	1.000	Q3ZCH0 →
Q01899	—	1.000	Q01899 →
Q5ZM98	—	1.000	Q5ZM98 →
P86233	—	1.000	P86233 →
P11141	—	1.000	P11141 →
P26413	—	1.000	P26413 →
Q9LDZ0	—	1.000	Q9LDZ0 →
P12076	—	0.999	P12076 →
P91902	—	0.999	P91902 →
Q8INI8	—	0.999	Q8INI8 →
P87047	—	0.999	P87047 →
Q9TUG3	—	0.998	Q9TUG3 →
Q8GUM2	—	0.998	Q8GUM2 →
P05456	—	0.998	P05456 →
P16394	—	0.998	P16394 →
Q48E62	—	0.998	Q48E62 →
P99502	—	0.998	P99502 →
Q9VG58	—	0.998	Q9VG58 →
Q6CQ83	—	0.997	Q6CQ83 →
B3CNB5	—	0.997	B3CNB5 →
Q3YRR6	—	0.997	Q3YRR6 →
P25840	—	0.997	P25840 →
P10591	—	0.997	P10591 →
Q9BIS2	—	0.997	Q9BIS2 →
P22954	—	0.997	P22954 →
P20163	—	0.997	P20163 →