Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | TYK2 | P29597 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641455 | 0.81 | KMT2A (0.37) | KDM4EALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL270972 | 0.79 | POLB (0.40) | ACLYKDM4EALDH1A1HSD17B10RPS6KA3 | |
| SCHEMBL3903095 | 0.75 | CREBBP (0.41) | ACLYKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL4825673 | 0.72 | RPS6KA3 (0.45) | RPS6KA3FGFR1JAK2JAK1TYK2 | |
| SCHEMBL4828067 | 0.72 | RPS6KA3 (0.45) | RPS6KA3ROCK2PIM1PIM3FGFR1 | |
| SCHEMBL854124 | 0.71 | KMT2A (0.34) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3938873 | 0.70 | RPS6KA3 (0.45) | KDM4EBRD4ALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL2156296 | 0.68 | BCL2L1 (0.38) | KDM4EALDH1A1HSD17B10RPS6KA3PIM1 | |
| SCHEMBL3941964 | 0.68 | RPS6KA3 (0.43) | RPS6KA3ROCK2PIM1PIM3PLAU | |
| SCHEMBL4554663 | 0.68 | RPS6KA3 (0.36) | KDM4EALDH1A1HSD17B10RPS6KA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183252-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2015-01-14 | — | — | EP | claimed |