Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 6/20 | 0.34 |
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16354331 | 0.81 | ACLY (0.36) | KMT2AALDH1A1MEN1KDM4EHSD17B10 | |
| SCHEMBL270972 | 0.80 | POLB (0.40) | KMT2AALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL11009537 | 0.77 | NOTUM (0.38) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL3903095 | 0.76 | CREBBP (0.41) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL3986117 | 0.74 | KMT2A (0.35) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL29851785 | 0.72 | HTR2A (0.40) | KMT2AALDH1A1HTR2AHTR2CTSHR | |
| SCHEMBL1864062 | 0.72 | HTR2A (0.40) | KMT2AALDH1A1HTR2AHTR2CTSHR | |
| SCHEMBL2156296 | 0.70 | BCL2L1 (0.38) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL4829875 | 0.70 | KMT2A (0.36) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL2421457 | 0.69 | KDM4E (0.49) | KMT2AALDH1A1MEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280978-B1 | PYRROLIDINE FUSED INDOLOBENZADIAZEPINE HCV NS5B INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-04-24 | — | — | EP | disclosed |
| US-8119628-B2 | Pyrrolidine fused indolobenzadiazepine HCV NS5B inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110020276-A1 | Pyrrolidine Fused Indolobenzadiazepine HCV NS5B Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2011-01-27 | — | — | US | disclosed |
| WO-2007092000-A1 | INHIBITORS OF HCV REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020276-A1 | Pyrrolidine Fused Indolobenzadiazepine HCV NS5B Inhibitors | NSD2, EIF2AK2, ZC3HAV1 | KMT2A 2930/4885ALDH1A1 1774/4885MEN1 4867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.