Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270972 | 0.82 | POLB (0.40) | KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL16354331 | 0.71 | ACLY (0.36) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2156296 | 0.69 | BCL2L1 (0.38) | ALDH1A1KDM4E | |
| SCHEMBL4826644 | 0.67 | RPS6KA3 (0.39) | — | |
| SCHEMBL4829943 | 0.64 | SMN1; SMN2 (0.37) | KMT2AMEN1SMN1; SMN2KDM4EPOLB | |
| Naphthalene SCHEMBL1131780 | 0.64 | KMT2A (0.69) | KMT2AMEN1ALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL29937281 | 0.64 | KMT2A (0.69) | KMT2AMEN1ALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL1563903 | 0.64 | KMT2A (0.69) | KMT2AMEN1ALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL809274 | 0.63 | KMT2A (0.55) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9230269 | 0.62 | KMT2A (0.61) | KMT2AMEN1ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183252-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2015-01-14 | — | — | EP | claimed |
| EP-2396329-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2014-10-29 | — | — | EP | claimed |
| EP-2178878-B1 | TETRACYCLIC COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2012-03-28 | — | — | EP | claimed |