Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404276 | 0.92 | TP53 (0.48) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL763575 | 0.92 | MAPT (0.46) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL8403103 | 0.92 | MAPT (0.47) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL765008 | 0.92 | MCHR1 (0.51) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL8403105 | 0.92 | MAPT (0.46) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL763655 | 0.90 | SIRT1 (0.47) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL9962159 | 0.90 | MAPT (0.45) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL763955 | 0.90 | MAPT (0.45) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL764244 | 0.90 | LMNA (0.52) | KIF11MAPTTP53SMN1; SMN2SIRT1 | |
| SCHEMBL764992 | 0.90 | MEN1 (0.48) | KIF11MAPTTP53SMN1; SMN2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005089764-A9 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2007-09-13 | — | — | WO | disclosed |