Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | CLPP | Q16740 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1636418 | 1.00 | MEN1 (0.47) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL4828073 | 0.80 | MEN1 (0.53) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL4915065 | 0.80 | CA2 (0.50) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL4915078 | 0.80 | CA2 (0.50) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL29018286 | 0.79 | CTSD (0.57) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL29018288 | 0.79 | CTSD (0.57) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL1634493 | 0.78 | POLB (0.52) | MEN1KMT2AALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL1635924 | 0.78 | POLB (0.52) | MEN1KMT2AALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL28442756 | 0.77 | MEN1 (0.51) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL4904714 | 0.75 | MEN1 (0.42) | MEN1KMT2ATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932266-B2 | Ester or amide derived from (3-sec-butyl-1-(thio)oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid; neurodegenerative diseases, cerebral and cardiac ischemias | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2011-04-26 | — | — | US | disclosed |
| US-7932266-B2 | Ester or amide derived from (3-sec-butyl-1-(thio)oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid; neurodegenerative diseases, cerebral and cardiac ischemias | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2011-04-26 | — | — | US | disclosed |
| US-7932266-B2 | Ester or amide derived from (3-sec-butyl-1-(thio)oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid; neurodegenerative diseases, cerebral and cardiac ischemias | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2011-04-26 | — | — | US | disclosed |
| US-20080090862-A1 | Isoquinoline Derivatives as Calpain Inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2008-04-17 | — | — | US | disclosed |
| US-20080090862-A1 | Isoquinoline Derivatives as Calpain Inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2008-04-17 | — | — | US | disclosed |
| US-20080090862-A1 | Isoquinoline Derivatives as Calpain Inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2008-04-17 | — | — | US | disclosed |
| EP-1829864-A1 | ISOQUINOLINE DERIVATIVES AS CALPAIN INHIBITORS | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006064075-A1 | ISOQUINOLINE DERIVATIVES AS CALPAIN INHIBITORS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090862-A1 | Isoquinoline Derivatives as Calpain Inhibitors | CAPN1, CAPN2, CAPNS1 | MEN1 4870/4885KMT2A 3888/4885TDP1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.