Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 13/20 | 0.73 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.73 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16364025 | 0.99 | TRPC5 (0.74) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16364002 | 0.97 | TRPC5 (0.77) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL19374971 | 0.93 | TRPC5 (0.71) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16076046 | 0.90 | TRPC5 (0.76) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL30171229 | 0.90 | TRPC5 (0.76) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16363496 | 0.88 | TRPC5 (0.62) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16028300 | 0.88 | TRPC5 (0.78) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16028243 | 0.88 | TRPC5 (0.94) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16364254 | 0.87 | TRPC5 (0.60) | TRPC5TRPC4TRPC1KCNH2PCSK9 | |
| SCHEMBL16028953 | 0.87 | TRPC5 (0.79) | TRPC5TRPC4TRPC1KCNH2PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014143799-A9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-12-24 | — | — | WO | disclosed |