Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135140 | 0.87 | HTR1A (0.41) | HTR1APDGFRBPDGFRAPSMB5CHRNB2 | |
| SCHEMBL17820514 | 0.81 | CYP2A6 (0.42) | HTR1APDGFRBPDGFRAPSMB5PRMT5 | |
| SCHEMBL16133341 | 0.80 | HTR1A (0.39) | HTR1APDGFRBPDGFRAPSMB5PPARA | |
| SCHEMBL13778365 | 0.75 | PSMB5 (0.48) | HTR1APDGFRBPDGFRAPSMB5PPARA | |
| SCHEMBL32661133 | 0.72 | PSMB5 (0.38) | HTR1APDGFRBPDGFRAPSMB5HDAC1 | |
| SCHEMBL3728063 | 0.71 | PDGFRB (0.41) | HTR1APDGFRBPDGFRAPSMB5CHRNB2 | |
| SCHEMBL32661412 | 0.71 | PSMB5 (0.38) | HTR1APSMB5HDAC1HDAC2ACMSD | |
| SCHEMBL32661309 | 0.71 | PSMB5 (0.38) | HTR1APSMB5HDAC1HDAC2ACMSD | |
| SCHEMBL16390248 | 0.71 | NOS1 (0.42) | CHRNB2CHRNA4PRMT5WDR77 | |
| SCHEMBL13778361 | 0.70 | PSMB5 (0.54) | PDGFRBPDGFRAPSMB5ACMSDCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-08-20 | — | — | US | disclosed |
| US-8916704-B1 | Dihydroquinone derivatives of piperidine and piperazine | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2014-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | HTR2C, HTR2A, HTR1B | HTR1A 6/4885PDGFRB 209/4885PDGFRA 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.