Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.67 |
| ▸ | SELE | P16581 | 1/20 | 0.67 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | RAD52 | P43351 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16375364 | 0.84 | EGFR (0.71) | EGFRKDM4EALDH1A1LMNARCE1 | |
| SCHEMBL29360504 | 0.82 | ICAM1 (0.72) | EGFRKDM4ELMNAICAM1SELE | |
| SCHEMBL4800479 | 0.82 | TEK (0.66) | EGFRKDM4EALDH1A1LMNARCE1 | |
| SCHEMBL4803681 | 0.81 | EGFR (0.58) | EGFRKDM4EALDH1A1LMNARCE1 | |
| SCHEMBL17200798 | 0.81 | FDPS (0.78) | EGFRKDM4EALDH1A1LMNARCE1 | |
| SCHEMBL5429540 | 0.80 | ICAM1 (1.00) | EGFRKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL15503823 | 0.80 | RAD52 (1.00) | EGFRKDM4EALDH1A1LMNARCE1 | |
| SCHEMBL11414153 | 0.77 | EGFR (0.64) | EGFRLMNAICAM1SELEVCAM1 | |
| SCHEMBL16376062 | 0.76 | EGFR (1.00) | EGFRICAM1SELEVCAM1 | |
| SCHEMBL16375358 | 0.74 | EGFR (1.00) | EGFRICAM1SELEVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015000959-A1 | 4-AMINO-6-ARYL[2,3-D]PYRIMIDINES FOR THE INHIBITION OF EGFR TYROSINE KINASE | NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU) (NO) | 2015-01-08 | — | — | WO | disclosed |