SCHEMBL16375381

SCHEMBL16375381

CCS(=O)(=O)c1ccc(N)nc1-c1nc2cc(C(F)(F)F)ccc2o1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UTRN P46939 5/20 0.44
PTPN2 P17706 4/20 0.41
PTPN1 P18031 4/20 0.41
PTPN5 P54829 4/20 0.41
HSPD1 P10809 2/20 0.41
HSPE1 P61604 2/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
GFER P55789 1/20 0.40
AGPAT2 O15120 1/20 0.40
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
HDAC6 Q9UBN7 2/20 0.39
CYP1A2 P05177 1/20 0.39
AHR P35869 1/20 0.39
BACE1 P56817 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methoxyamine SCHEMBL17726160 0.96 UTRN (0.46) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL16375186 0.89 AGPAT2 (0.46) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL17733125 0.88 UTRN (0.42) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL18327932 0.84 ALDH1A1 (0.47) UTRNNPC1RAB9AAGPAT2MEN1
SCHEMBL18498722 0.84 ALOX5AP (0.35) UTRNBACE1
SCHEMBL16376341 0.84 UTRN (0.42) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL15933541 0.83 UTRN (0.42) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL29431584 0.83 UTRN (0.42) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL16375901 0.83 AGPAT2 (0.43) UTRNPTPN2PTPN1PTPN5HSPD1
SCHEMBL18819691 0.82 UTRN (0.47) UTRNPTPN2PTPN1PTPN5HSPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3018130-B1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF SUMITOMO CHEMICAL CO (JP) 2021-08-04 EP disclosed
EP-3018130-B1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF SUMITOMO CHEMICAL CO (JP) 2021-08-04 EP disclosed
US-9920050-B2 Fused heterocyclic compound and pest control use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-03-20 US disclosed
US-9920050-B2 Fused heterocyclic compound and pest control use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-03-20 US disclosed
US-20160368915-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-12-22 US disclosed
US-20160368915-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-12-22 US disclosed
EP-3018130-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF Sumitomo Chemical Company, Limited (JP) 2016-05-11 EP disclosed
EP-3018130-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF Sumitomo Chemical Company, Limited (JP) 2016-05-11 EP disclosed
WO-2015002211-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF 住友化学株式会社 (JP) 2015-01-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160368915-A1 FUSED HETEROCYCLIC COMPOUND AND PEST CONTROL USE THEREOF CBR3, NOX5, CBR1 UTRN 4514/4885PTPN2 2957/4885PTPN1 2678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.