Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28488286 | 0.84 | TSHR (0.48) | CYP11B2KIF11MEN1MAPTKMT2A | |
| SCHEMBL17683703 | 0.82 | ADORA2A (0.49) | MEN1ALDH1A1KMT2AHRH3APP | |
| SCHEMBL19719159 | 0.81 | SYK (0.48) | SYKABCB1ABCG2SLC6A2SLC6A4 | |
| SCHEMBL20615103 | 0.81 | ABCB1 (0.48) | SYKABCB1ABCG2HSD11B1SLC6A2 | |
| SCHEMBL13006754 | 0.81 | MMP3 (0.52) | ABCB1ABCG2HSD11B1CYP11B2KIF11 | |
| SCHEMBL22507033 | 0.80 | MMP3 (0.56) | SLC6A2SLC6A4SLC6A3CYP11B2KIF11 | |
| SCHEMBL361389 | 0.79 | MAPT (0.53) | SYKABCG2MEN1ALDH1A1MAPT | |
| SCHEMBL1038467 | 0.78 | TSHR (0.59) | SYKMEN1ALDH1A1KMT2A | |
| SCHEMBL30288275 | 0.78 | TSHR (0.59) | SYKMEN1ALDH1A1KMT2A | |
| SCHEMBL19233947 | 0.78 | EGLN2 (0.44) | SYKABCB1ABCG2CYP11B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9844535-B2 | SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2017-12-19 | — | — | US | disclosed |
| US-9522881-B2 | Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-12-20 | — | — | US | disclosed |
| US-20160102054-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-04-14 | — | — | US | disclosed |
| WO-2015003094-A2 | SHP2 INHIBITORS AND METHODS OF TREATING AUTOIMMUNE AND/OR GLOMERULONEPHRITIS-ASSOCIATED DISEASES USING SHP2 INHIBITORS | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102054-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | SRC, PTPRCAP, PTPRJ | SYK 82/4885ABCB1 4425/4885ABCG2 2397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.