Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377514 | 0.76 | MAPT (0.34) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL16377513 | 0.74 | GLO1 (0.33) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL14425301 | 0.74 | HSP90AA1 (0.41) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL1148539 | 0.73 | HSP90AA1 (0.43) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL1343801 | 0.73 | HSP90AA1 (0.43) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL1148620 | 0.71 | HSP90AA1 (0.40) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL1340870 | 0.71 | GAA (0.45) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL12046415 | 0.71 | HSP90AA1 (0.41) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL12046543 | 0.71 | HSP90AA1 (0.46) | HSP90AA1ALOX12ALOX15GAAMAPT | |
| SCHEMBL14609789 | 0.70 | HSP90AA1 (0.42) | HSP90AA1ALOX12ALOX15GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921407-B2 | Pyrazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2014-12-30 | — | — | US | disclosed |