Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16377514 | 0.84 | MAPT (0.34) | GLO1HSP90AA1GAAMGAMSI | |
| SCHEMBL16377458 | 0.83 | HSP90AA1 (0.32) | GLO1HSP90AA1GAAMGAMSI | |
| SCHEMBL16377501 | 0.74 | HSP90AA1 (0.39) | HSP90AA1GAALMNAMEN1MAPT | |
| SCHEMBL1148655 | 0.68 | CA12 (0.35) | HSP90AA1GAALMNAMEN1MAPT | |
| SCHEMBL13100013 | 0.67 | SIRT5 (0.32) | GAALMNAMEN1MAPTHTT | |
| SCHEMBL1148560 | 0.66 | PIK3CD (0.38) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL12553693 | 0.65 | CHEK1 (0.36) | HSP90AA1GAALMNAMEN1MAPT | |
| SCHEMBL1342318 | 0.64 | SIRT5 (0.35) | HSP90AA1GAALMNAMEN1MAPT | |
| SCHEMBL12553695 | 0.64 | ESR1 (0.39) | HSP90AA1GAAMEN1MAPTKMT2A | |
| SCHEMBL1342355 | 0.64 | JAK1 (0.32) | HSP90AA1GAALMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921407-B2 | Pyrazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2014-12-30 | — | — | US | disclosed |