SCHEMBL163779

SCHEMBL163779

C#CCOc1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARG P13631 12/20 0.70
RARB P10826 11/20 0.70
RARA P10276 11/20 0.70
MEN1 O00255 3/20 0.70
KMT2A Q03164 3/20 0.70
NR1I2 O75469 1/20 0.70
LMNA P02545 1/20 0.70
PGR P06401 1/20 0.70
HSPD1 P10809 1/20 0.70
GOT1 P17174 1/20 0.70
GLRA1 P23415 1/20 0.70
BLM P54132 1/20 0.70
HSPE1 P61604 1/20 0.70
TDP1 Q9NUW8 1/20 0.70
KDM4E B2RXH2 1/20 0.63
ALDH1A1 P00352 1/20 0.63
TP53 P04637 1/20 0.63
CYP3A4 P08684 1/20 0.63
MAPT P10636 1/20 0.63
HPGD P15428 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30153290 1.00 RARG (0.70) RARGRARBRARAMEN1KMT2A
SCHEMBL7077350 0.89 RARB (0.61) RARGRARBRARAMEN1KMT2A
SCHEMBL8766163 0.86 RARG (0.74) RARGRARBRARAMEN1KMT2A
SCHEMBL30817478 0.85 RARB (0.49) RARGRARBRARAMEN1KMT2A
SCHEMBL5081246 0.84 RARB (0.74) RARGRARBRARAMEN1KMT2A
SCHEMBL8767123 0.84 RARG (0.70) RARGRARBRARAMEN1KMT2A
SCHEMBL22929249 0.83 RARB (0.69) RARGRARBRARAMEN1KMT2A
SCHEMBL30015507 0.83 RARB (0.69) RARGRARBRARAMEN1KMT2A
Hydrochloric Acid SCHEMBL8765869 0.83 RARG (0.69) RARGRARBRARAMEN1KMT2A
SCHEMBL980744 0.83 RARB (0.72) RARGRARBRARAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4066826-B1 RETINOIC ACID RECEPTOR GAMMA AGONISTS FOR MUSCLE REPAIR AND REGENERATION UNIV JEFFERSON (US) 2024-03-06 EP claimed
EP-4066826-A1 RETINOIC ACID RECEPTOR GAMMA AGONISTS FOR MUSCLE REPAIR AND REGENERATION Thomas Jefferson University (US) 2022-10-05 EP claimed
US-11433039-B2 Composition and method for muscle repair and regeneration THOMAS JEFFERSON UNIVERSITY (US) 2022-09-06 US claimed
EP-2613776-B1 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION UNIV JEFFERSON (US) 2020-07-29 EP claimed
US-20200069620-A1 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION THOMAS JEFFERSON UNIVERSITY 2020-03-05 US claimed
US-9789074-B2 Composition and method for muscle repair and regeneration THOMAS JEFFERSON UNIVERSITY (US) 2017-10-17 US claimed
US-20140363402-A1 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION THOMAS JEFFERSON UNIVERSITY (US) 2014-12-11 US claimed
EP-2613776-A2 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION Thomas Jefferson University (US) 2013-07-17 EP claimed
WO-2012030919-A2 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION THOMAS JEFFERSON UNIVERSITY (US) 2012-03-08 WO claimed
US-6686386-B1 COMBATING PHOTOINDUCED OR CHRONOLOGICAL AGEING OF SKIN WITH RETENOIC ACID RECEPTOR AGONIST GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-03 US claimed
US-20030092758-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 2003-05-15 US claimed
US-20010018456-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis FESUS LASZLO (HU) 2001-08-30 US claimed
US-20250108022-A1 COMPOSITION AND METHOD FOR MUSCLE REPAIR AND REGENERATION THOMAS JEFFERSON UNIVERSITY 2025-04-03 US disclosed
US-12023312-B2 Composition and method for muscle repair and regeneration THOMAS JEFFERSON UNIVERSITY (US) 2024-07-02 US disclosed
EP-4066826-B1 RETINOIC ACID RECEPTOR GAMMA AGONISTS FOR MUSCLE REPAIR AND REGENERATION UNIV JEFFERSON (US) 2024-03-06 EP disclosed
US-20230346727-A1 COMPOUNDS FOR THE TREATMENT OF HEMOPHILIA UNIVERSITE GRENOBLE ALPES (FR) 2023-11-02 US disclosed
US-20030092758-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 2003-05-15 US disclosed
US-20030092758-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 2003-05-15 US disclosed
US-6506796-B1 Cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2003-01-14 US disclosed
US-20010018456-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis FESUS LASZLO (HU) 2001-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346727-A1 COMPOUNDS FOR THE TREATMENT OF HEMOPHILIA PROC, F2, F8 RARG 1713/4885RARB 1848/4885RARA 1675/4885
US-20030092758-A1 Use of a RAR-gamma-specific agonist ligand for increasing the rate of apoptosis RARA, RARB, RARG RARG 3/4885RARB 2/4885RARA 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.