Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985684 | 0.91 | SLC1A3 (0.69) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL14985686 | 0.88 | SLC1A3 (0.59) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL14985688 | 0.86 | SLC1A3 (0.57) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL20782480 | 0.85 | LMNA (0.60) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL15505928 | 0.84 | SLC1A3 (0.55) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL16299891 | 0.84 | LMNA (0.58) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL18375320 | 0.84 | LMNA (0.58) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL14985685 | 0.83 | SLC1A3 (0.54) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL9564585 | 0.83 | SLC1A3 (0.59) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL12658531 | 0.83 | SLC1A3 (0.62) | SLC1A3SLC1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927534-B2 | Compounds for the inhibition of integrins and use thereof | SHIRE ORPHAN THERAPIES GMBH (DE) | 2015-01-06 | — | — | US | disclosed |