Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CD44 | P16070 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21522156 | 0.82 | PNMT (0.32) | PNMTASIC3CD44HTR2AHTR2C | |
| SCHEMBL16220595 | 0.82 | PNMT (0.52) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL16217188 | 0.79 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL30474281 | 0.79 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL1593053 | 0.79 | NOS3 (0.56) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL25173279 | 0.79 | PNMT (0.53) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL30403469 | 0.79 | PNMT (0.53) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL19042532 | 0.79 | PNMT (0.44) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL16209946 | 0.75 | PNMT (0.47) | PNMTADRA2AADRA2BADRA2CCHRM2 | |
| SCHEMBL19678844 | 0.75 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2CCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296761-B2 | Triazine derivatives | PFIZER INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150353579-A1 | Triazine Derivatives | PFIZER (US) | 2015-12-10 | — | — | US | disclosed |
| US-8933224-B2 | Triazine derivatives | PFIZER INC. (US) | 2015-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353579-A1 | Triazine Derivatives | PDE12, PDE5A, PDE10A | PNMT 750/4885ADRA2A 95/4885ADRA2B 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.