Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.67 |
| ▸ | NPC1 | O15118 | 13/20 | 0.67 |
| ▸ | RAB9A | P51151 | 13/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | STAT3 | P40763 | 1/20 | 0.67 |
| ▸ | STAT1 | P42224 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.66 |
| ▸ | HPGD | P15428 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.64 |
| ▸ | RELA | Q04206 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917694 | 0.76 | ALDH1A1 (0.97) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17660254 | 0.74 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20787904 | 0.74 | NPC1 (0.74) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791867 | 0.73 | ALDH1A1 (0.75) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791865 | 0.73 | ALDH1A1 (0.73) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17664600 | 0.73 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL14916543 | 0.73 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20130531 | 0.73 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20788541 | 0.72 | SMN1; SMN2 (0.60) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL14825278 | 0.71 | ALDH1A1 (0.57) | ALDH1A1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| WO-2014210319-A2 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE 1 AS ANTI-PARASITIC COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | SLC29A1, SLC29A2, SLC28A1 | ALDH1A1 982/4885NPC1 144/4885RAB9A 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.