Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.73 |
| ▸ | NPC1 | O15118 | 13/20 | 0.73 |
| ▸ | RAB9A | P51151 | 13/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.73 |
| ▸ | STAT1 | P42224 | 1/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.71 |
| ▸ | HPGD | P15428 | 10/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.69 |
| ▸ | RELA | Q04206 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20787904 | 0.82 | NPC1 (0.74) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791867 | 0.81 | ALDH1A1 (0.75) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791870 | 0.80 | NPC1 (0.74) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791863 | 0.80 | ALDH1A1 (0.73) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20791864 | 0.79 | ALDH1A1 (0.69) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17660254 | 0.77 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17660285 | 0.75 | ALDH1A1 (0.69) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20788544 | 0.73 | NPC1 (0.61) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16384137 | 0.73 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20788542 | 0.73 | NPC1 (0.60) | ALDH1A1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |