Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16384160 | 0.89 | PPARA (0.50) | PPARGPPARACTSKCTSSATM | |
| SCHEMBL18653949 | 0.85 | CTSK (0.58) | PPARGPPARACTSKCTSSATM | |
| SCHEMBL4727222 | 0.85 | CTSK (0.58) | PPARGPPARACTSKCTSSATM | |
| Hydrochloric Acid SCHEMBL4899166 | 0.84 | CTSK (0.57) | PPARGPPARACTSKCTSSATM | |
| SCHEMBL16384170 | 0.83 | PPARA (0.54) | PPARGPPARACTSKCTSSCA2 | |
| SCHEMBL13970938 | 0.83 | PPARG (0.49) | PPARGPPARACTSKCTSSATM | |
| SCHEMBL12475133 | 0.81 | PPARA (0.64) | PPARGPPARACTSKCTSS | |
| SCHEMBL12475131 | 0.81 | PPARA (0.64) | PPARGPPARACTSKCTSS | |
| SCHEMBL31407637 | 0.81 | PPARA (0.64) | PPARGPPARACTSKCTSS | |
| SCHEMBL16384482 | 0.81 | CTSK (0.52) | PPARGPPARACTSKCTSSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673281-B1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | REMPEX PHARMACEUTICALS INC (US) | 2016-04-13 | — | — | EP | disclosed |
| US-8933018-B2 | Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2015-01-13 | — | — | US | disclosed |