Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.54 |
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | CTSK | P43235 | 6/20 | 0.51 |
| ▸ | CTSS | P25774 | 6/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475133 | 0.89 | PPARA (0.64) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL31407637 | 0.89 | PPARA (0.64) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL12475131 | 0.89 | PPARA (0.64) | PPARAPPARGCTSKCTSSPPARD | |
| SCHEMBL19033721 | 0.86 | CTSK (0.54) | PPARAPPARGCTSKCTSSCA2 | |
| SCHEMBL19901844 | 0.85 | CTSK (0.53) | PPARAPPARGCTSKCTSSCA2 | |
| SCHEMBL6802106 | 0.85 | CTSK (0.68) | PPARAPPARGCTSKCTSSREN | |
| Valine SCHEMBL2747379 | 0.83 | PPARA (0.56) | PPARAPPARGCTSKCTSSCA2 | |
| SCHEMBL28578199 | 0.83 | PPARA (0.53) | PPARAPPARGCTSKCTSSCA2 | |
| SCHEMBL16384171 | 0.83 | PPARG (0.49) | PPARAPPARGCTSKCTSSCA2 | |
| SCHEMBL25054091 | 0.83 | PPARA (0.55) | PPARAPPARGCTSKCTSSCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673281-B1 | BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF | REMPEX PHARMACEUTICALS INC (US) | 2016-04-13 | — | — | EP | disclosed |
| US-8933018-B2 | Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2015-01-13 | — | — | US | disclosed |