Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 7/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 7/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39855 | 0.79 | CARM1 (0.54) | CYP2C19CARM1PRMT6PRMT8PRMT1 | |
| SCHEMBL3314840 | 0.79 | CARM1 (0.54) | CYP2C19CARM1PRMT6PRMT8PRMT1 | |
| SCHEMBL1098678 | 0.79 | POLB (0.47) | CYP2C19POLBRXFP1TP53SMN1; SMN2 | |
| SCHEMBL1098682 | 0.79 | POLB (0.50) | CYP2C19POLBRXFP1HRH2HRH1 | |
| SCHEMBL13452456 | 0.79 | HRH2 (0.48) | CYP2C19POLBRXFP1HRH2HRH1 | |
| SCHEMBL24127292 | 0.79 | CARM1 (0.48) | CYP2C19CARM1PRMT6PRMT8PRMT1 | |
| SCHEMBL13347946 | 0.79 | CARM1 (0.48) | CYP2C19CARM1PRMT6PRMT8PRMT1 | |
| SCHEMBL18908760 | 0.78 | SMN1; SMN2 (0.47) | CYP2C19POLBRXFP1TP53SMN1; SMN2 | |
| SCHEMBL11501237 | 0.78 | CARM1 (0.52) | CYP2C19CARM1PRMT6PRMT8POLB | |
| SCHEMBL24208750 | 0.78 | POLB (0.46) | CYP2C19POLBRXFP1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | ENSEMBLE THERAPEUTICS CORPORATION | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005319-A1 | MACROCYCLIC COMPOUNDS FOR MODULATING IL-17 | IL17A, IL15, IL2 | CYP2C19 95/4885CARM1 2553/4885PRMT6 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.