Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29698008 | 0.77 | MAPT (0.61) | NPC1RAB9AAHRMEN1KMT2A | |
| SCHEMBL16353693 | 0.77 | MAPT (0.61) | NPC1RAB9AAHRMEN1KMT2A | |
| SCHEMBL16386143 | 0.74 | TDP1 (0.50) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2614738 | 0.71 | KMT2A (0.61) | NPC1GAAMEN1KMT2APOLB | |
| SCHEMBL11853387 | 0.71 | KMT2A (0.78) | NPC1RAB9AGAAMEN1KMT2A | |
| SCHEMBL8970981 | 0.70 | PTK2 (0.70) | NPC1RAB9AGAAAHRMEN1 | |
| SCHEMBL29870304 | 0.70 | MAPT (0.76) | NPC1RAB9AGAAAHRMEN1 | |
| SCHEMBL20228918 | 0.70 | MAPT (0.76) | NPC1RAB9AGAAAHRMEN1 | |
| SCHEMBL7300821 | 0.70 | RAB9A (0.66) | NPC1RAB9AGAAAHRMEN1 | |
| SCHEMBL12172813 | 0.69 | CREBBP (0.52) | NPC1RAB9AGAAAHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015004212-A1 | INHIBITOR OF NEUROPILIN AND USE THEREOF FOR THE TREATMENT OF NEUROPILIN-RELATED DISEASES | TRAGEX PHARMA (FR) | 2015-01-15 | — | — | WO | disclosed |
| EP-2823816-A1 | Inhibitors of Neuropilin and use thereof for the treatment of Neuropilin-related diseases | Tragex Pharma (FR) | 2015-01-14 | — | — | EP | disclosed |