Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724753 | 0.82 | SMN1; SMN2 (0.59) | MEN1KMT2ASMN1; SMN2USP2MAPK1 | |
| SCHEMBL16250560 | 0.82 | LMNA (0.51) | MEN1KMT2ATSHRSMN1; SMN2USP2 | |
| SCHEMBL455309 | 0.81 | MEN1 (0.59) | MEN1KMT2AGAAMAPTDRD4 | |
| SCHEMBL3879539 | 0.81 | CHEK1 (0.48) | MEN1KMT2ASCN8AUSP2ALDH1A1 | |
| SCHEMBL3457044 | 0.81 | HRH3 (0.51) | MEN1KMT2ASMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL3457092 | 0.79 | CHRM2 (0.51) | MEN1KMT2ASMN1; SMN2USP2CA1 | |
| SCHEMBL4713979 | 0.79 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL5792628 | 0.79 | L3MBTL1 (0.55) | MEN1KMT2ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL3622998 | 0.79 | HRH4 (0.52) | MEN1KMT2ASMN1; SMN2SCN8AUSP2 | |
| SCHEMBL4717200 | 0.78 | CYP1A2 (0.53) | MEN1KMT2AUSP2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404907-B1 | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-01-14 | — | — | EP | disclosed |