Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.44 |
| ▸ | PLK1 | P53350 | 5/20 | 0.44 |
| ▸ | VRK1 | Q99986 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STK4 | Q13043 | 3/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.32 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14952202 | 0.87 | PIN1 (0.39) | PLK2PLK1MAPTPIN1HCRTR2 | |
| SCHEMBL13814861 | 0.85 | PIN1 (0.41) | VRK1MAPTSTK4PIN1BRD4 | |
| SCHEMBL13814860 | 0.85 | MAPT (0.39) | PLK2PLK1VRK1MAPTPIN1 | |
| SCHEMBL2026027 | 0.84 | PLK2 (0.62) | PLK2PLK1 | |
| SCHEMBL15826167 | 0.82 | PLK1 (0.37) | PLK2PLK1VRK1BRD4LOX | |
| SCHEMBL16371646 | 0.82 | PLK1 (0.37) | PLK2PLK1VRK1BRD4LOX | |
| SCHEMBL21492526 | 0.79 | STK4 (0.50) | VRK1STK4RPS6KA3BRD4 | |
| SCHEMBL21261610 | 0.79 | STK4 (0.50) | VRK1STK4RPS6KA3BRD4 | |
| SCHEMBL4079498 | 0.79 | MAPT (0.39) | PLK2PLK1VRK1MAPTSTK4 | |
| SCHEMBL21493004 | 0.75 | VRK1 (0.46) | PLK2PLK1VRK1STK4RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516441-B1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-01-21 | — | — | EP | disclosed |