Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | STK4 | Q13043 | 3/20 | 0.35 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089875 | 0.81 | VRK1 (0.41) | PLK1VRK1HPGDBRD4 | |
| SCHEMBL16390761 | 0.79 | PLK2 (0.44) | MAPTPLK2PLK1STK4VRK1 | |
| SCHEMBL1202898 | 0.78 | MAPT (0.43) | MAPTPLK1PIN1ALDH1A1POLB | |
| SCHEMBL3670859 | 0.76 | GAA (0.42) | MAPTUSP2ALDH1A1POLBHPGD | |
| SCHEMBL4106908 | 0.76 | SMN1; SMN2 (0.40) | MAPTPLK2PLK1PIN1ALDH1A1 | |
| SCHEMBL13814857 | 0.76 | MAPT (0.43) | MAPTPIN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1559401 | 0.75 | MAPT (0.41) | MAPTPLK2PLK1STK4PIN1 | |
| SCHEMBL12323830 | 0.75 | MAPT (0.49) | MAPTPIN1ALDH1A1POLBHPGD | |
| SCHEMBL12323364 | 0.75 | MAPT (0.49) | MAPTPIN1ALDH1A1POLBHPGD | |
| SCHEMBL14599887 | 0.75 | ALDH1A1 (0.43) | MAPTUSP2ALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517873-B2 | Substituted pyrimidodiazepines | HOFFMAN-LA ROCHE INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234255-A1 | SUBSTITUTED PYRIMIDODIAZEPINES | PLK1, CCNI, CDK1 | MAPT 2296/4885PLK2 5/4885PLK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.