Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | NPC1 | O15118 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | GCGR | P47871 | 1/20 | 0.67 |
| ▸ | IDO1 | P14902 | 2/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.62 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639479 | 1.00 | RRM1 (0.77) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12766750 | 1.00 | RRM1 (0.77) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29366011 | 0.87 | RRM1 (1.00) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1637574 | 0.87 | RRM1 (1.00) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4454258 | 0.87 | RRM1 (1.00) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1637575 | 0.87 | RRM1 (1.00) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL22245273 | 0.84 | GCGR (0.76) | MEN1KMT2ANPC1RAB9AGCGR | |
| SCHEMBL20115427 | 0.84 | GCGR (0.76) | MEN1KMT2ANPC1RAB9AGCGR | |
| SCHEMBL16035633 | 0.84 | MEN1 (0.81) | RRM1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14906922 | 0.84 | MEN1 (0.81) | RRM1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | RRM1 3099/4885MEN1 2974/4885KMT2A 3625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.