Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 5/20 | 1.00 |
| ▸ | IDO1 | P14902 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.70 |
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.67 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29366011 | 1.00 | RRM1 (1.00) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL1637575 | 1.00 | RRM1 (1.00) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL1637574 | 1.00 | RRM1 (1.00) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL18963239 | 0.88 | RRM1 (1.00) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL1639477 | 0.87 | RRM1 (0.77) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL1639479 | 0.87 | RRM1 (0.77) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL12766750 | 0.87 | RRM1 (0.77) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL683715 | 0.85 | MEN1 (0.85) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL2847708 | 0.85 | MEN1 (0.85) | RRM1IDO1MEN1KMT2ANPC1 | |
| SCHEMBL7602938 | 0.84 | RRM1 (0.72) | RRM1IDO1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962677-B2 | Methods of restoring cognitive ability using non-peptidic compounds | ACUMEN PHARMACEUTICALS, INC. (US) | 2015-02-24 | — | — | US | claimed |
| EP-2173340-B1 | METHODS OF ENHANCING COGNITIVE FUNCTION USING NON-PEPTIDIC COMPOUNDS | ACUMEN PHARMACEUTICALS INC (US) | 2013-07-10 | — | — | EP | claimed |
| US-12011432-B2 | Method of modulating ribonucleotide reductase | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-06-18 | — | — | US | disclosed |
| US-20210299095-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | CASE WESTERN RESERVE UNIVERSITY | 2021-09-30 | — | — | US | disclosed |
| US-20180360782-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | UNIV CASE WESTERN RESERVE (US) | 2018-12-20 | — | — | US | disclosed |
| EP-3377053-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | Case Western Reserve University (US) | 2018-09-26 | — | — | EP | disclosed |
| WO-2017100644-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-06-15 | — | — | WO | disclosed |
| WO-2017100644-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-06-15 | — | — | WO | disclosed |
| US-20150320860-A1 | METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42 | MERCK SHARP AND DOHME CORP. | 2015-11-12 | — | — | US | disclosed |
| EP-2928561-A1 | METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42 | Acumen Pharmaceuticals, Inc. (US) | 2015-10-14 | — | — | EP | disclosed |
| US-8962677-B2 | Methods of restoring cognitive ability using non-peptidic compounds | ACUMEN PHARMACEUTICALS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962677-B2 | Methods of restoring cognitive ability using non-peptidic compounds | ACUMEN PHARMACEUTICALS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962677-B2 | Methods of restoring cognitive ability using non-peptidic compounds | ACUMEN PHARMACEUTICALS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2014089149-A1 | METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42 | ACUMEN PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | WO | disclosed |
| EP-2173340-B1 | METHODS OF ENHANCING COGNITIVE FUNCTION USING NON-PEPTIDIC COMPOUNDS | ACUMEN PHARMACEUTICALS INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| US-20090018084-A1 | METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. | 2009-01-15 | — | — | US | disclosed |
| US-20090018084-A1 | METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. | 2009-01-15 | — | — | US | disclosed |
| US-20090018084-A1 | METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. | 2009-01-15 | — | — | US | disclosed |
| WO-2009009768-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018084-A1 | METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS | BCHE, APP, ACHE | RRM1 3967/4885IDO1 2004/4885MEN1 2353/4885 |
| US-20210299095-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | RRM2, RRM2B, RRM1 | RRM1 3/4885IDO1 2335/4885MEN1 3447/4885 |
| US-20180360782-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | RRM2, RRM2B, RRM1 | RRM1 3/4885IDO1 3024/4885MEN1 3193/4885 |
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | RRM1 3099/4885IDO1 1981/4885MEN1 2974/4885 |
| US-12011432-B2 | Method of modulating ribonucleotide reductase | RRM2, RRM2B, RRM1 | RRM1 3/4885IDO1 2335/4885MEN1 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.