Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 13/20 | 0.55 |
| ▸ | F11 | P03951 | 12/20 | 0.55 |
| ▸ | TPSB2 | P20231 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.39 |
| ▸ | PLG | P00747 | 4/20 | 0.39 |
| ▸ | PLAU | P00749 | 4/20 | 0.39 |
| ▸ | F7 | P08709 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F9 | P00740 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | PLAT | P00750 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397266 | 1.00 | CFD (0.55) | CFDF11TPSB2HPGDMEN1 | |
| SCHEMBL16397586 | 0.89 | CFD (0.55) | CFDF11TPSB2HPGDMEN1 | |
| SCHEMBL16402498 | 0.87 | CFD (0.54) | CFDF11TPSB2HPGDKLKB1 | |
| SCHEMBL16402197 | 0.83 | CFD (0.40) | CFDF11TPSB2HPGDMEN1 | |
| SCHEMBL16397461 | 0.81 | MEN1 (0.52) | HPGDMEN1LMNAKMT2ACCR5 | |
| SCHEMBL16410526 | 0.79 | CFD (0.72) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764367 | 0.79 | CFD (0.72) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397048 | 0.77 | CFD (0.54) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16396177 | 0.76 | HPGD (0.49) | HPGDMEN1LMNAKMT2ACCR5 | |
| SCHEMBL16410444 | 0.75 | CFD (0.44) | CFDF11TPSB2HPGDKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |