Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397009 | 0.88 | MEN1 (0.48) | MEN1KMT2ALMNACCR5PKM | |
| SCHEMBL16396177 | 0.87 | HPGD (0.49) | MEN1KMT2ALMNACCR5PKM | |
| SCHEMBL16402498 | 0.83 | CFD (0.54) | CCR5HPGD | |
| SCHEMBL16397264 | 0.81 | CFD (0.55) | MEN1KMT2ALMNACCR5PKM | |
| SCHEMBL16397266 | 0.81 | CFD (0.55) | MEN1KMT2ALMNACCR5PKM | |
| SCHEMBL16402197 | 0.81 | CFD (0.40) | MEN1KMT2ALMNAHPGDMAPT | |
| SCHEMBL16397048 | 0.78 | CFD (0.54) | CCR5 | |
| SCHEMBL16410444 | 0.77 | CFD (0.44) | CCR5HPGDGAAMAPTL3MBTL1 | |
| SCHEMBL16397586 | 0.77 | CFD (0.55) | MEN1KMT2ALMNACCR5HPGD | |
| SCHEMBL23218370 | 0.76 | HPGD (0.43) | MEN1KMT2ALMNACCR5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |