Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.42 |
| ▸ | FNTB | P49356 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | PADI3 | Q9ULW8 | 4/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.41 |
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922934 | 0.82 | FFAR1 (0.47) | CYP2C9CYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL16396868 | 0.80 | AOC3 (0.58) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL2450156 | 0.78 | AOC3 (0.56) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL16396984 | 0.78 | AOC3 (0.60) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL2454247 | 0.77 | AOC3 (0.59) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL5581782 | 0.77 | AOC3 (0.49) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL8059189 | 0.77 | CYP1A2 (0.68) | AOC3CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL15687811 | 0.77 | HDAC6 (0.56) | CFD | |
| SCHEMBL22501609 | 0.76 | PRMT6 (0.62) | AOC3CYP2C9CYP2D6 | |
| SCHEMBL20497351 | 0.76 | SRC (0.58) | AOC3CYP2C9CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160145247-A1 | Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof | NOVARTIS AG (CH) | 2016-05-26 | — | — | US | disclosed |
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145247-A1 | Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof | CFD, CFH, CFB | AOC3 600/4885CYP2C9 228/4885CYP1A2 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.