Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397929 | 0.89 | MALT1 (0.37) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL16398232 | 0.78 | NPC1 (0.33) | MEN1ALDH1A1KMT2A | |
| SCHEMBL16398055 | 0.77 | IDH1 (0.42) | — | |
| SCHEMBL16398065 | 0.74 | MEN1 (0.40) | MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL16398285 | 0.72 | ESR1 (0.57) | — | |
| SCHEMBL16397831 | 0.72 | TACR1 (0.36) | ALDH1A1 | |
| SCHEMBL16398007 | 0.72 | IL1B (0.38) | ALDH1A1 | |
| SCHEMBL16398422 | 0.72 | CYP1A2 (0.37) | ALDH1A1 | |
| SCHEMBL16398389 | 0.71 | HTR2A (0.34) | — | |
| SCHEMBL16398255 | 0.71 | THRB (0.33) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004079-B1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | ACTURUM REAL ESTATE AB (SE) | 2018-01-17 | — | — | EP | disclosed |
| US-9439904-B2 | Pyrimidine compounds and their use as gamma secretase modulators | Acturum Life Science AB (SE) | 2016-09-13 | — | — | US | disclosed |
| US-9439904-B2 | Pyrimidine compounds and their use as gamma secretase modulators | Acturum Life Science AB (SE) | 2016-09-13 | — | — | US | disclosed |
| US-9439904-B2 | Pyrimidine compounds and their use as gamma secretase modulators | Acturum Life Science AB (SE) | 2016-09-13 | — | — | US | disclosed |
| US-20160129002-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | Acturum Life Science AB (SE) | 2016-05-12 | — | — | US | disclosed |
| US-20160129002-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | Acturum Life Science AB (SE) | 2016-05-12 | — | — | US | disclosed |
| US-20160129002-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | Acturum Life Science AB (SE) | 2016-05-12 | — | — | US | disclosed |
| EP-3004079-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | Acturum Life Science AB (SE) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014195323-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | Acturum Life Science AB (SE) | 2014-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160129002-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS | BACE1, BACE2, APP | MEN1 3205/4885ALDH1A1 1476/4885GAA 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.