Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16409414 | 0.90 | GPR119 (0.40) | MEN1KMT2ACHRM3GPR119 | |
| SCHEMBL516800 | 0.81 | MEN1 (0.40) | BACE1MEN1KMT2ACHRM3CHRM1 | |
| SCHEMBL16401254 | 0.81 | BACE1 (0.36) | BACE1MEN1KMT2ACHRM3 | |
| SCHEMBL26985459 | 0.80 | MEN1 (0.41) | MEN1KMT2AGPR119 | |
| SCHEMBL30065370 | 0.79 | MEN1 (0.38) | BACE1MEN1KMT2ACHRM3CHRM1 | |
| SCHEMBL5880292 | 0.77 | BACE1 (0.39) | BACE1 | |
| SCHEMBL15032343 | 0.77 | GPR119 (0.55) | MEN1KMT2AGPR119 | |
| SCHEMBL14945259 | 0.76 | MEN1 (0.38) | BACE1MEN1KMT2ACHRM3CHRM1 | |
| SCHEMBL31441735 | 0.76 | BRD4 (0.44) | BACE1KMT2A | |
| SCHEMBL31441697 | 0.76 | BRD4 (0.44) | BACE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |