Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5400401 | 0.91 | MAOB (0.55) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL5400405 | 0.91 | MAOB (0.55) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL2383875 | 0.89 | MEN1 (0.47) | MAOBMAOAADAM17NPC1ALDH1A1 | |
| SCHEMBL4416405 | 0.85 | MAOB (0.43) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL4416398 | 0.85 | MAOB (0.43) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL6930389 | 0.84 | MAOB (0.53) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL5614017 | 0.82 | MAOB (0.41) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL4297619 | 0.76 | PTGER4 (0.43) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL12493203 | 0.73 | MAOB (0.46) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL4796989 | 0.73 | MAOB (0.46) | MAOBMAOAMMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022225-B1 | TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES | UNIV TEXAS (US) | 2021-09-29 | — | — | EP | disclosed |
| US-20160168235-A1 | TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | disclosed |
| EP-3022225-A2 | TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES | Board Of Regents Of the University Of Texas System (US) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015010118-A2 | TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES | THE UNIVERSITY OF TEXAS (US) | 2015-01-22 | — | — | WO | disclosed |