Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 3/20 | 0.38 |
| ▸ | CASP6 | P55212 | 3/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930389 | 0.84 | MAOB (0.53) | MAOBMAOAALDH1A1MMP2MMP9 | |
| SCHEMBL4264976 | 0.83 | OPRD1 (0.55) | BACE1 | |
| SCHEMBL3370165 | 0.83 | CASP3 (0.46) | MAOBCASP3MEN1KMT2APSMB8 | |
| SCHEMBL2383875 | 0.83 | MEN1 (0.47) | MAOBMAOAMMP8ALDH1A1ADAM17 | |
| SCHEMBL16401469 | 0.82 | MAOB (0.49) | MAOBMAOAALDH1A1POLBMMP2 | |
| SCHEMBL2157759 | 0.81 | OPRD1 (0.52) | BACE1 | |
| SCHEMBL4321426 | 0.81 | BACE1 (0.44) | CASP3BACE1 | |
| SCHEMBL3366840 | 0.80 | CASP1 (0.51) | CASP3BACE1 | |
| SCHEMBL4297619 | 0.79 | PTGER4 (0.43) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL5180148 | 0.78 | TAS1R3 (0.40) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865977-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | The Burnham Institute for Medical Research (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006102068-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | THE BURNHAM INSTITUTE (US) | 2006-09-28 | — | — | WO | disclosed |
| WO-2003045974-A2 | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE | THE BURNHAM INSTITUTE (US) | 2003-06-05 | — | — | WO | disclosed |