SCHEMBL1640227

SCHEMBL1640227

Cc1ccc(Nc2ccc3c(c2)Oc2cc(Nc4ccc(F)cc4C)ccc2C32OC(=O)c3ccccc32)c(C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 7/20 0.47
MAPT P10636 5/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
HTT P42858 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
CYP2C19 P33261 2/20 0.47
HPGD P15428 1/20 0.47
RECQL P46063 1/20 0.47
BLM P54132 1/20 0.47
SMAD3 P84022 1/20 0.47
PRMT1 Q99873 1/20 0.47
ACE2 Q9BYF1 1/20 0.47
CYP3A4 P08684 2/20 0.45
LMNA P02545 5/20 0.44
USP2 O75604 1/20 0.44
ALDH1A1 P00352 1/20 0.44
NPSR1 Q6W5P4 3/20 0.42
POLB P06746 2/20 0.42
ALOX12 P18054 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1639350 0.96 FTO (0.51) FTOMAPTMEN1KMT2AHTT
SCHEMBL1639993 0.91 FTO (0.47) FTOMAPTMEN1KMT2AHTT
SCHEMBL1639333 0.91 FTO (0.47) FTOMAPTMEN1KMT2AHTT
SCHEMBL10520882 0.86 FTO (0.53) FTOMAPTMEN1KMT2AHTT
SCHEMBL1638516 0.83 FTO (0.46) FTOMAPTMEN1KMT2AHTT
SCHEMBL1640404 0.82 CYP3A4 (0.44) FTOMAPTMEN1KMT2AHTT
SCHEMBL25633972 0.82 CYP3A4 (0.54) FTOMAPTMEN1KMT2AHTT
SCHEMBL10518377 0.82 FTO (0.59) FTOMAPTMEN1KMT2AHTT
SCHEMBL1638523 0.80 CYP3A4 (0.53) FTOMAPTMEN1KMT2AHTT
SCHEMBL1640135 0.80 FTO (0.56) FTOMAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110098487-A1 NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS ZINK IMAGING, INC. 2011-04-28 US disclosed
US-7807607-B2 Color-forming compounds and use thereof in imaging members and methods ZINK IMAGING, INC. (US) 2010-10-05 US disclosed
WO-2010075544-A1 NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS ZINK IMAGING, INC. (US) 2010-07-01 WO disclosed
US-20090137389-A1 NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS ZINK IMAGING, INC. 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098487-A1 NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS HCCS, RB1, CACYBP FTO 2797/4885MAPT 520/4885MEN1 2050/4885
US-20090137389-A1 NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS HCCS, RB1, CACYBP FTO 2797/4885MAPT 520/4885MEN1 2050/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.