Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30141966 | 1.00 | KDM1A (0.45) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL25053490 | 0.83 | KDM1A (0.34) | KDM1AMAOBSLC6A2SLC6A4PRCP | |
| SCHEMBL25052830 | 0.82 | KCNH2 (0.40) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL8085859 | 0.80 | SMN1; SMN2 (0.49) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL22032451 | 0.79 | KDM1A (0.40) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL16401194 | 0.79 | KDM1A (0.40) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL22032415 | 0.79 | KDM1A (0.40) | KDM1AMAOBCISD1SLC6A2HTR1B | |
| SCHEMBL29324146 | 0.78 | GRIN2B (0.47) | KDM1ASLC6A4MAOAMEN1KMT2A | |
| SCHEMBL29081462 | 0.78 | GRIN2B (0.47) | KDM1ASLC6A4MAOAMEN1KMT2A | |
| SCHEMBL25053184 | 0.78 | KDM1A (0.47) | KDM1ASIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | claimed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | claimed |
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |