Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATP4A | P20648 | 2/20 | 0.44 |
| ▸ | ATP4B | P51164 | 2/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404013 | 0.94 | ATP4A (0.49) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL14224933 | 0.91 | NPC1 (0.48) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL14224909 | 0.90 | POLB (0.47) | POLBKMT2AATP4AATP4BWNT3A | |
| SCHEMBL14315467 | 0.88 | MGLL (0.51) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL14318378 | 0.87 | MGLL (0.50) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL16404015 | 0.87 | ATP4A (0.48) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL14150274 | 0.86 | JAK3 (0.51) | POLBKMT2AATP4AATP4BNPC1 | |
| Hydrochloric Acid SCHEMBL14150343 | 0.85 | JAK3 (0.51) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL14318313 | 0.85 | JAK3 (0.51) | POLBKMT2AATP4AATP4BNPC1 | |
| SCHEMBL16404017 | 0.84 | ATP4A (0.45) | POLBKMT2AATP4AATP4BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |